LRP1-CAND1 Fusion FISH Probe
The LRP1-CAND1 Fusion FISH Probe is used to confirm a fusion of the LRP1 and CAND1 genes. The fusion of the LRP1 and CAND1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP1-CAND1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-RERE | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-REOR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-REGO | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-REGR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-OROR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GORE | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GROR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP1-CAND1-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP1 Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Gene Name: LDL Receptor Related Protein 1
Chromosome: CHR12: 57522281 -57607125
Locus: 12q13.3
CAND1 Gene Summary
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Gene Name: Cullin Associated And Neddylation Dissociated 1
Chromosome: CHR12: 67663060 -67708388
Locus: 12q14.3-q15
Gene Diseases
The LRP1 CAND1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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