LRP1-ATF1 Fusion FISH Probe
The LRP1-ATF1 Fusion FISH Probe is used to confirm a fusion of the LRP1 and ATF1 genes. The fusion of the LRP1 and ATF1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP1-ATF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-RERE | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-REOR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-REGO | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-REGR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-OROR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GORE | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GROR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP1-ATF1-20-AQAQ | 20 (40 μL) | 200 μL |
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ATF1 Gene Summary
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
Gene Name: Activating Transcription Factor 1
Chromosome: CHR12: 51157788 -51214943
Locus: 12q13.12
LRP1 Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Gene Name: LDL Receptor Related Protein 1
Chromosome: CHR12: 57522281 -57607125
Locus: 12q13.3
Gene Diseases
The LRP1 ATF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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