LRCH1-NUDT15 Fusion FISH Probe
The LRCH1-NUDT15 Fusion FISH Probe is used to confirm a fusion of the LRCH1 and NUDT15 genes. The fusion of the LRCH1 and NUDT15 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRCH1-NUDT15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-RERE | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-REOR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-REGO | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-REGR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-REAQ | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-ORRE | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-OROR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-ORGO | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GORE | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GOOR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GOGO | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GOGR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GRRE | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GROR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GRGO | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GRGR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-AQRE | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-AQOR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-AQGO | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-AQGR | 20 (40 μL) | 200 μL |
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| LRCH1-NUDT15-20-AQAQ | 20 (40 μL) | 200 μL |
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LRCH1 Gene Summary
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]
Gene Name: Leucine Rich Repeats And Calponin Homology Domain Containing 1
Chromosome: CHR13: 47127295 -47327175
Locus: 13q14.13-q14.2
NUDT15 Gene Summary
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
Gene Name: Nudix Hydrolase 15
Chromosome: CHR13: 48611702 -48621282
Locus: 13q14.2
Gene Diseases
The LRCH1 NUDT15 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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