LRBA-SH3D19 Fusion FISH Probe
The LRBA-SH3D19 Fusion FISH Probe is used to confirm a fusion of the LRBA and SH3D19 genes. The fusion of the LRBA and SH3D19 genes has been associated with Lung Squamous Cell Carcinoma, Head And Neck Squamous Cell Carcinoma , Colon Adenocarcinoma, Bladder Urothelial Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRBA-SH3D19-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-RERE | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-REOR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-REGO | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-REGR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-REAQ | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-ORRE | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-OROR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-ORGO | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GORE | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GOOR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GOGO | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GOGR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GRRE | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GROR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GRGO | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GRGR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-AQRE | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-AQOR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-AQGO | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-AQGR | 20 (40 μL) | 200 μL |
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| LRBA-SH3D19-20-AQAQ | 20 (40 μL) | 200 μL |
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LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
SH3D19 Gene Summary
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: SH3 Domain Containing 19
Chromosome: CHR4: 152041432 -152149182
Locus: 4q31.3
Gene Diseases
The LRBA SH3D19 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
| Colon Adenocarcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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