LRBA-RXFP1 Fusion FISH Probe
The LRBA-RXFP1 Fusion FISH Probe is used to confirm a fusion of the LRBA and RXFP1 genes. The fusion of the LRBA and RXFP1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRBA-RXFP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-RERE | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-REOR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-REGO | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-REGR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-REAQ | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-ORRE | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-OROR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-ORGO | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GORE | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GOOR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GOGO | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GOGR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GRRE | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GROR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GRGO | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GRGR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-AQRE | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-AQOR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-AQGO | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-AQGR | 20 (40 μL) | 200 μL |
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| LRBA-RXFP1-20-AQAQ | 20 (40 μL) | 200 μL |
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LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
RXFP1 Gene Summary
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Relaxin/insulin Like Family Peptide Receptor 1
Chromosome: CHR4: 159443046 -159573263
Locus: 4q32.1
Gene Diseases
The LRBA RXFP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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