LRBA-HFE2 Fusion FISH Probe
The LRBA-HFE2 Fusion FISH Probe is used to confirm a fusion of the LRBA and HFE2 genes. The fusion of the LRBA and HFE2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRBA-HFE2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-RERE | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-REOR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-REGO | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-REGR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-REAQ | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-ORRE | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-OROR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-ORGO | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GORE | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GOOR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GOGO | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GOGR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GRRE | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GROR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GRGO | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GRGR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-AQRE | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-AQOR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-AQGO | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-AQGR | 20 (40 μL) | 200 μL |
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| LRBA-HFE2-20-AQAQ | 20 (40 μL) | 200 μL |
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LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
HFE2 Gene Summary
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
Gene Name: Hemochromatosis Type 2 (juvenile)
Chromosome: CHR1: 145413190 -145417545
Locus: 1q21.1
Gene Diseases
The LRBA HFE2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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