LRBA-CHCHD3 Fusion FISH Probe
The LRBA-CHCHD3 Fusion FISH Probe is used to confirm a fusion of the LRBA and CHCHD3 genes. The fusion of the LRBA and CHCHD3 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRBA-CHCHD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-RERE | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-REOR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-REGO | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-REGR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-REAQ | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-ORRE | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-OROR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-ORGO | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GORE | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GOOR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GOGO | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GOGR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GRRE | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GROR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GRGO | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GRGR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-AQRE | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-AQOR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-AQGO | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-AQGR | 20 (40 μL) | 200 μL |
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| LRBA-CHCHD3-20-AQAQ | 20 (40 μL) | 200 μL |
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LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
CHCHD3 Gene Summary
The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: Coiled-coil-helix-coiled-coil-helix Domain Containing 3
Chromosome: CHR7: 132469622 -132766828
Locus: 7q32.3-q33
Gene Diseases
The LRBA CHCHD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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