LPP-ZNRF1 Fusion FISH Probe
The LPP-ZNRF1 Fusion FISH Probe is used to confirm a fusion of the LPP and ZNRF1 genes. The fusion of the LPP and ZNRF1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LPP-ZNRF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-RERE | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-REOR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-REGO | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-REGR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-OROR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GORE | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GROR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| LPP-ZNRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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LPP Gene Summary
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: LIM Domain Containing Preferred Translocation Partner In Lipoma
Chromosome: CHR3: 187871662 -188608460
Locus: 3q27.3-q28
ZNRF1 Gene Summary
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Gene Name: Zinc And Ring Finger 1
Chromosome: CHR16: 75032914 -75144892
Locus: 16q23.1
Gene Diseases
The LPP ZNRF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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