LPP-F2 Fusion FISH Probe
The LPP-F2 Fusion FISH Probe is used to confirm a fusion of the LPP and F2 genes. The fusion of the LPP and F2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LPP-F2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LPP-F2-20-RERE | 20 (40 μL) | 200 μL |
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| LPP-F2-20-REOR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-REGO | 20 (40 μL) | 200 μL |
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| LPP-F2-20-REGR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-REAQ | 20 (40 μL) | 200 μL |
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| LPP-F2-20-ORRE | 20 (40 μL) | 200 μL |
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| LPP-F2-20-OROR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-ORGO | 20 (40 μL) | 200 μL |
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| LPP-F2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GORE | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GOOR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GOGO | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GOGR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GRRE | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GROR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GRGO | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GRGR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LPP-F2-20-AQRE | 20 (40 μL) | 200 μL |
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| LPP-F2-20-AQOR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-AQGO | 20 (40 μL) | 200 μL |
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| LPP-F2-20-AQGR | 20 (40 μL) | 200 μL |
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| LPP-F2-20-AQAQ | 20 (40 μL) | 200 μL |
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F2 Gene Summary
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Gene Name: Coagulation Factor II, Thrombin
Chromosome: CHR11: 46740742 -46761056
Locus: 11p11.2
LPP Gene Summary
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: LIM Domain Containing Preferred Translocation Partner In Lipoma
Chromosome: CHR3: 187871662 -188608460
Locus: 3q27.3-q28
Gene Diseases
The LPP F2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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