LPP-CASR Fusion FISH Probe
The LPP-CASR Fusion FISH Probe is used to confirm a fusion of the LPP and CASR genes. The fusion of the LPP and CASR genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LPP-CASR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-RERE | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-REOR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-REGO | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-REGR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-REAQ | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-ORRE | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-OROR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-ORGO | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-ORAQ | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GORE | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GOOR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GOGO | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GOGR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GOAQ | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GRRE | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GROR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GRGO | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GRGR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-GRAQ | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-AQRE | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-AQOR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-AQGO | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-AQGR | 20 (40 μL) | 200 μL |
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| LPP-CASR-20-AQAQ | 20 (40 μL) | 200 μL |
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CASR Gene Summary
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
Gene Name: Calcium Sensing Receptor
Chromosome: CHR3: 121902529 -122005344
Locus: 3q13.33-q21.1
LPP Gene Summary
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: LIM Domain Containing Preferred Translocation Partner In Lipoma
Chromosome: CHR3: 187871662 -188608460
Locus: 3q27.3-q28
Gene Diseases
The LPP CASR Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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