LONP2-HIRA Fusion FISH Probe
The LONP2-HIRA Fusion FISH Probe is used to confirm a fusion of the LONP2 and HIRA genes. The fusion of the LONP2 and HIRA genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LONP2-HIRA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-RERE | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-REOR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-OROR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| LONP2-HIRA-20-AQAQ | 20 (40 μL) | 200 μL |
|
HIRA Gene Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Gene Name: Histone Cell Cycle Regulator
Chromosome: CHR22: 19318223 -19419219
Locus: 22q11.21
LONP2 Gene Summary
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Lon Peptidase 2, Peroxisomal
Chromosome: CHR16: 48278210 -48387407
Locus: 16q12.1
Gene Diseases
The LONP2 HIRA Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|