LONP2-EGLN3 Fusion FISH Probe
The LONP2-EGLN3 Fusion FISH Probe is used to confirm a fusion of the LONP2 and EGLN3 genes. The fusion of the LONP2 and EGLN3 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LONP2-EGLN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-RERE | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-REOR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-REGO | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-REGR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-REAQ | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-ORRE | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-OROR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-ORGO | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GORE | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GOOR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GOGO | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GOGR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GRRE | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GROR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GRGO | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GRGR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-AQRE | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-AQOR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-AQGO | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-AQGR | 20 (40 μL) | 200 μL |
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| LONP2-EGLN3-20-AQAQ | 20 (40 μL) | 200 μL |
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LONP2 Gene Summary
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Lon Peptidase 2, Peroxisomal
Chromosome: CHR16: 48278210 -48387407
Locus: 16q12.1
EGLN3 Gene Summary
The Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) gene is located on chr14 :34393420-34420284 at 14q13.1.
Gene Name: Egl-9 Family Hypoxia Inducible Factor 3
Chromosome: CHR14: 34393420 -34420284
Locus: 14q13.1
Gene Diseases
The LONP2 EGLN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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