LONP2-CHRM3 Fusion FISH Probe
The LONP2-CHRM3 Fusion FISH Probe is used to confirm a fusion of the LONP2 and CHRM3 genes. The fusion of the LONP2 and CHRM3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LONP2-CHRM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-RERE | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-REOR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-REGO | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-REGR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-REAQ | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-ORRE | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-OROR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-ORGO | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GORE | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GOOR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GOGO | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GOGR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GRRE | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GROR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GRGO | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GRGR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-AQRE | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-AQOR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-AQGO | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-AQGR | 20 (40 μL) | 200 μL |
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| LONP2-CHRM3-20-AQAQ | 20 (40 μL) | 200 μL |
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CHRM3 Gene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Gene Name: Cholinergic Receptor Muscarinic 3
Chromosome: CHR1: 239792372 -240072717
Locus: 1q43
LONP2 Gene Summary
In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Lon Peptidase 2, Peroxisomal
Chromosome: CHR16: 48278210 -48387407
Locus: 16q12.1
Gene Diseases
The LONP2 CHRM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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