LONP1-RANBP3 Fusion FISH Probe
The LONP1-RANBP3 Fusion FISH Probe is used to confirm a fusion of the LONP1 and RANBP3 genes. The fusion of the LONP1 and RANBP3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LONP1-RANBP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-RERE | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-REOR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-REGO | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-REGR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-REAQ | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-ORRE | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-OROR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-ORGO | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GORE | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GOOR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GOGO | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GOGR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GRRE | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GROR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GRGO | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GRGR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-AQRE | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-AQOR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-AQGO | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-AQGR | 20 (40 μL) | 200 μL |
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| LONP1-RANBP3-20-AQAQ | 20 (40 μL) | 200 μL |
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RANBP3 Gene Summary
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: RAN Binding Protein 3
Chromosome: CHR19: 5916151 -5978320
Locus: 19p13.3
LONP1 Gene Summary
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Name: Lon Peptidase 1, Mitochondrial
Chromosome: CHR19: 5691844 -5720176
Locus: 19p13.3
Gene Diseases
The LONP1 RANBP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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