LONP1-RAD51 Fusion FISH Probe
The LONP1-RAD51 Fusion FISH Probe is used to confirm a fusion of the LONP1 and RAD51 genes. The fusion of the LONP1 and RAD51 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LONP1-RAD51-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-RERE | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-REOR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-REGO | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-REGR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-REAQ | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-ORRE | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-OROR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-ORGO | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-ORAQ | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GORE | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GOOR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GOGO | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GOGR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GOAQ | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GRRE | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GROR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GRGO | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GRGR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-GRAQ | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-AQRE | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-AQOR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-AQGO | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-AQGR | 20 (40 μL) | 200 μL |
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| LONP1-RAD51-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD51 Gene Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Name: RAD51 Recombinase
Chromosome: CHR15: 40987326 -41024356
Locus: 15q15.1
LONP1 Gene Summary
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Name: Lon Peptidase 1, Mitochondrial
Chromosome: CHR19: 5691844 -5720176
Locus: 19p13.3
Gene Diseases
The LONP1 RAD51 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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