LONP1-DDX27 Fusion FISH Probe
The LONP1-DDX27 Fusion FISH Probe is used to confirm a fusion of the LONP1 and DDX27 genes. The fusion of the LONP1 and DDX27 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LONP1-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| LONP1-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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LONP1 Gene Summary
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Name: Lon Peptidase 1, Mitochondrial
Chromosome: CHR19: 5691844 -5720176
Locus: 19p13.3
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The LONP1 DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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