LNX1-IFT122 Fusion FISH Probe
The LNX1-IFT122 Fusion FISH Probe is used to confirm a fusion of the LNX1 and IFT122 genes. The fusion of the LNX1 and IFT122 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LNX1-IFT122-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-RERE | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-REOR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-REGO | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-REGR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-REAQ | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-ORRE | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-OROR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-ORGO | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-ORAQ | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GORE | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GOOR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GOGO | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GOGR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GOAQ | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GRRE | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GROR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GRGO | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GRGR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-GRAQ | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-AQRE | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-AQOR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-AQGO | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-AQGR | 20 (40 μL) | 200 μL |
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| LNX1-IFT122-20-AQAQ | 20 (40 μL) | 200 μL |
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IFT122 Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Name: Intraflagellar Transport 122
Chromosome: CHR3: 129158967 -129239191
Locus: 3q21.3-q22.1
LNX1 Gene Summary
This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ligand Of Numb-protein X 1
Chromosome: CHR4: 54326436 -54457724
Locus: 4q12
Gene Diseases
The LNX1 IFT122 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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