LMTK2-PCLO Fusion FISH Probe
The LMTK2-PCLO Fusion FISH Probe is used to confirm a fusion of the LMTK2 and PCLO genes. The fusion of the LMTK2 and PCLO genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMTK2-PCLO-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-RERE | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-REOR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-REGO | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-REGR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-REAQ | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-ORRE | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-OROR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-ORGO | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GORE | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GOOR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GOGO | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GOGR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GRRE | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GROR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GRGO | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GRGR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-AQRE | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-AQOR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-AQGO | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-AQGR | 20 (40 μL) | 200 μL |
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| LMTK2-PCLO-20-AQAQ | 20 (40 μL) | 200 μL |
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LMTK2 Gene Summary
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Gene Name: Lemur Tyrosine Kinase 2
Chromosome: CHR7: 97736196 -97838944
Locus: 7q21.3
PCLO Gene Summary
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Piccolo Presynaptic Cytomatrix Protein
Chromosome: CHR7: 82383320 -82792197
Locus: 7q21.11
Gene Diseases
The LMTK2 PCLO Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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