LMNA-IGFBP2 Fusion FISH Probe
The LMNA-IGFBP2 Fusion FISH Probe is used to confirm a fusion of the LMNA and IGFBP2 genes. The fusion of the LMNA and IGFBP2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMNA-IGFBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-RERE | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-REOR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-REGO | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-REGR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-OROR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GORE | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GROR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| LMNA-IGFBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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IGFBP2 Gene Summary
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Insulin Like Growth Factor Binding Protein 2
Chromosome: CHR2: 217498126 -217529158
Locus: 2q35
LMNA Gene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Gene Name: Lamin A/C
Chromosome: CHR1: 156084460 -156109878
Locus: 1q22
Gene Diseases
The LMNA IGFBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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