LMBR1L-VDR Fusion FISH Probe
The LMBR1L-VDR Fusion FISH Probe is used to confirm a fusion of the LMBR1L and VDR genes. The fusion of the LMBR1L and VDR genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMBR1L-VDR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-RERE | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-REOR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-REGO | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-REGR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-REAQ | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-ORRE | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-OROR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-ORGO | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GORE | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GOOR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GOGO | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GOGR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GRRE | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GROR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GRGO | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GRGR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-AQRE | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-AQOR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-AQGO | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-AQGR | 20 (40 μL) | 200 μL |
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| LMBR1L-VDR-20-AQAQ | 20 (40 μL) | 200 μL |
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VDR Gene Summary
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
Gene Name: Vitamin D Receptor
Chromosome: CHR12: 48235319 -48298814
Locus: 12q13.11
LMBR1L Gene Summary
The Limb Development Membrane Protein 1 Like (LMBR1L) gene is located on chr12 :49490922-49504680 at 12q13.12.
Gene Name: Limb Development Membrane Protein 1 Like
Chromosome: CHR12: 49490922 -49504680
Locus: 12q13.12
Gene Diseases
The LMBR1L VDR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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