LMBR1-PTPRN2 Fusion FISH Probe
The LMBR1-PTPRN2 Fusion FISH Probe is used to confirm a fusion of the LMBR1 and PTPRN2 genes. The fusion of the LMBR1 and PTPRN2 genes has been associated with Breast Invasive Carcinoma, Breast Invasive Carcinoma, Prostate Adenocarcinoma, and Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMBR1-PTPRN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-RERE | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-REOR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-REGO | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-REGR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-REAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-ORRE | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-OROR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-ORGO | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GORE | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GOOR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GOGO | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GOGR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GRRE | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GROR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GRGO | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GRGR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-AQRE | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-AQOR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-AQGO | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-AQGR | 20 (40 μL) | 200 μL |
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| LMBR1-PTPRN2-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRN2 Gene Summary
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type N2
Chromosome: CHR7: 157331749 -158380482
Locus: 7q36.3
LMBR1 Gene Summary
This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]
Gene Name: Limb Development Membrane Protein 1
Chromosome: CHR7: 156473569 -156685902
Locus: 7q36.3
Gene Diseases
The LMBR1 PTPRN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
| Prostate Adenocarcinoma |
| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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