LMBR1-PRSS1 Fusion FISH Probe
The LMBR1-PRSS1 Fusion FISH Probe is used to confirm a fusion of the LMBR1 and PRSS1 genes. The fusion of the LMBR1 and PRSS1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMBR1-PRSS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-RERE | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-REOR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-REGO | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-REGR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-REAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-ORRE | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-OROR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-ORGO | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GORE | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GOOR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GOGO | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GOGR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GRRE | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GROR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GRGO | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GRGR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-AQRE | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-AQOR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-AQGO | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-AQGR | 20 (40 μL) | 200 μL |
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| LMBR1-PRSS1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRSS1 Gene Summary
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Gene Name: Protease, Serine 1
Chromosome: CHR7: 142457318 -142460927
Locus: 7q34
LMBR1 Gene Summary
This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]
Gene Name: Limb Development Membrane Protein 1
Chromosome: CHR7: 156473569 -156685902
Locus: 7q36.3
Gene Diseases
The LMBR1 PRSS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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