LMAN2L-MRPS5 Fusion FISH Probe
The LMAN2L-MRPS5 Fusion FISH Probe is used to confirm a fusion of the LMAN2L and MRPS5 genes. The fusion of the LMAN2L and MRPS5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMAN2L-MRPS5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-RERE | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-REOR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-REGO | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-REGR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-REAQ | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-ORRE | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-OROR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-ORGO | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GORE | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GOOR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GOGO | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GOGR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GRRE | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GROR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GRGO | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GRGR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-AQRE | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-AQOR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-AQGO | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-AQGR | 20 (40 μL) | 200 μL |
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| LMAN2L-MRPS5-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPS5 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S5
Chromosome: CHR2: 95752951 -95787754
Locus: 2q11.1
LMAN2L Gene Summary
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Gene Name: Lectin, Mannose Binding 2 Like
Chromosome: CHR2: 97371666 -97405813
Locus: 2q11.2
Gene Diseases
The LMAN2L MRPS5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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