LMAN2-F12 Fusion FISH Probe
The LMAN2-F12 Fusion FISH Probe is used to confirm a fusion of the LMAN2 and F12 genes. The fusion of the LMAN2 and F12 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LMAN2-F12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-RERE | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-REOR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-REGO | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-REGR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-REAQ | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-ORRE | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-OROR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-ORGO | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-ORAQ | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GORE | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GOOR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GOGO | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GOGR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GOAQ | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GRRE | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GROR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GRGO | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GRGR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-GRAQ | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-AQRE | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-AQOR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-AQGO | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-AQGR | 20 (40 μL) | 200 μL |
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| LMAN2-F12-20-AQAQ | 20 (40 μL) | 200 μL |
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F12 Gene Summary
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
Gene Name: Coagulation Factor XII
Chromosome: CHR5: 176829138 -176836577
Locus: 5q35.3
LMAN2 Gene Summary
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
Gene Name: Lectin, Mannose Binding 2
Chromosome: CHR5: 176758562 -176778885
Locus: 5q35.3
Gene Diseases
The LMAN2 F12 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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