LMAN2-DOCK2 Fusion FISH Probe
The LMAN2-DOCK2 Fusion FISH Probe is used to confirm a fusion of the LMAN2 and DOCK2 genes. The fusion of the LMAN2 and DOCK2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LMAN2-DOCK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| LMAN2-DOCK2-20-AQAQ | 20 (40 μL) | 200 μL |
|
DOCK2 Gene Summary
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
Gene Name: Dedicator Of Cytokinesis 2
Chromosome: CHR5: 169064250 -169510386
Locus: 5q35.1
LMAN2 Gene Summary
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
Gene Name: Lectin, Mannose Binding 2
Chromosome: CHR5: 176758562 -176778885
Locus: 5q35.3
Gene Diseases
The LMAN2 DOCK2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|