LIN9-KDM5B Fusion FISH Probe
The LIN9-KDM5B Fusion FISH Probe is used to confirm a fusion of the LIN9 and KDM5B genes. The fusion of the LIN9 and KDM5B genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LIN9-KDM5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-RERE | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-REOR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-REGO | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-REGR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-REAQ | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-ORRE | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-OROR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-ORGO | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GORE | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GOOR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GOGO | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GOGR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GRRE | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GROR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GRGO | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GRGR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-AQRE | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-AQOR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-AQGO | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-AQGR | 20 (40 μL) | 200 μL |
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| LIN9-KDM5B-20-AQAQ | 20 (40 μL) | 200 μL |
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KDM5B Gene Summary
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Lysine Demethylase 5B
Chromosome: CHR1: 202696531 -202777549
Locus: 1q32.1
LIN9 Gene Summary
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Lin-9 DREAM MuvB Core Complex Component
Chromosome: CHR1: 226418860 -226497198
Locus: 1q42.12
Gene Diseases
The LIN9 KDM5B Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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