LIMK2-CDC45 Fusion FISH Probe
The LIMK2-CDC45 Fusion FISH Probe is used to confirm a fusion of the LIMK2 and CDC45 genes. The fusion of the LIMK2 and CDC45 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LIMK2-CDC45-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-RERE | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-REOR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-REGO | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-REGR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-REAQ | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-ORRE | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-OROR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-ORGO | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-ORAQ | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GORE | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GOOR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GOGO | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GOGR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GOAQ | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GRRE | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GROR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GRGO | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GRGR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-GRAQ | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-AQRE | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-AQOR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-AQGO | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-AQGR | 20 (40 μL) | 200 μL |
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| LIMK2-CDC45-20-AQAQ | 20 (40 μL) | 200 μL |
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LIMK2 Gene Summary
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: LIM Domain Kinase 2
Chromosome: CHR22: 31608249 -31676066
Locus: 22q12.2
CDC45 Gene Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Cell Division Cycle 45
Chromosome: CHR22: 19467413 -19508135
Locus: 22q11.21
Gene Diseases
The LIMK2 CDC45 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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