LIG3-HAP1 Fusion FISH Probe
The LIG3-HAP1 Fusion FISH Probe is used to confirm a fusion of the LIG3 and HAP1 genes. The fusion of the LIG3 and HAP1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LIG3-HAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-RERE | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-REOR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-REGO | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-REGR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-OROR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GORE | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GROR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| LIG3-HAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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LIG3 Gene Summary
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: DNA Ligase 3
Chromosome: CHR17: 33307516 -33332088
Locus: 17q12
HAP1 Gene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Huntingtin Associated Protein 1
Chromosome: CHR17: 39878890 -39890898
Locus: 17q21.2
Gene Diseases
The LIG3 HAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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