LIFR-PNPLA8 Fusion FISH Probe
The LIFR-PNPLA8 Fusion FISH Probe is used to confirm a fusion of the LIFR and PNPLA8 genes. The fusion of the LIFR and PNPLA8 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LIFR-PNPLA8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-RERE | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-REOR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-REGO | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-REGR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-REAQ | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-ORRE | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-OROR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-ORGO | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-ORAQ | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GORE | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GOOR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GOGO | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GOGR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GOAQ | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GRRE | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GROR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GRGO | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GRGR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-GRAQ | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-AQRE | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-AQOR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-AQGO | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-AQGR | 20 (40 μL) | 200 μL |
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| LIFR-PNPLA8-20-AQAQ | 20 (40 μL) | 200 μL |
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LIFR Gene Summary
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: LIF Receptor Alpha
Chromosome: CHR5: 38475064 -38595507
Locus: 5p13.1
PNPLA8 Gene Summary
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]
Gene Name: Patatin Like Phospholipase Domain Containing 8
Chromosome: CHR7: 108112070 -108166638
Locus: 7q31.1
Gene Diseases
The LIFR PNPLA8 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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