LGR5-PPFIA2 Fusion FISH Probe
The LGR5-PPFIA2 Fusion FISH Probe is used to confirm a fusion of the LGR5 and PPFIA2 genes. The fusion of the LGR5 and PPFIA2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LGR5-PPFIA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| LGR5-PPFIA2-20-AQAQ | 20 (40 μL) | 200 μL |
|
PPFIA2 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: PTPRF Interacting Protein Alpha 2
Chromosome: CHR12: 81652044 -82153109
Locus: 12q21.31
LGR5 Gene Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Leucine Rich Repeat Containing G Protein-coupled Receptor 5
Chromosome: CHR12: 71833812 -71978621
Locus: 12q21.1
Gene Diseases
The LGR5 PPFIA2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|