LGALS8-EDARADD Fusion FISH Probe
The LGALS8-EDARADD Fusion FISH Probe is used to confirm a fusion of the LGALS8 and EDARADD genes. The fusion of the LGALS8 and EDARADD genes has been associated with Breast Invasive Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LGALS8-EDARADD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-RERE | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-REOR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-REGO | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-REGR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-REAQ | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-ORRE | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-OROR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-ORGO | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-ORAQ | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GORE | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GOOR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GOGO | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GOGR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GOAQ | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GRRE | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GROR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GRGO | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GRGR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-GRAQ | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-AQRE | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-AQOR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-AQGO | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-AQGR | 20 (40 μL) | 200 μL |
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| LGALS8-EDARADD-20-AQAQ | 20 (40 μL) | 200 μL |
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LGALS8 Gene Summary
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Galectin 8
Chromosome: CHR1: 236681513 -236716279
Locus: 1q43
EDARADD Gene Summary
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: EDAR Associated Death Domain
Chromosome: CHR1: 236557679 -236648008
Locus: 1q42.3-q43
Gene Diseases
The LGALS8 EDARADD Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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