LETM1-MXD4 Fusion FISH Probe
The LETM1-MXD4 Fusion FISH Probe is used to confirm a fusion of the LETM1 and MXD4 genes. The fusion of the LETM1 and MXD4 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LETM1-MXD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-RERE | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-REOR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-REGO | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-REGR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-REAQ | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-ORRE | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-OROR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-ORGO | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GORE | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GOOR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GOGO | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GOGR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GRRE | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GROR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GRGO | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GRGR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-AQRE | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-AQOR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-AQGO | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-AQGR | 20 (40 μL) | 200 μL |
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| LETM1-MXD4-20-AQAQ | 20 (40 μL) | 200 μL |
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LETM1 Gene Summary
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
Gene Name: Leucine Zipper And EF-hand Containing Transmembrane Protein 1
Chromosome: CHR4: 1813205 -1857974
Locus: 4p16.3
MXD4 Gene Summary
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Gene Name: MAX Dimerization Protein 4
Chromosome: CHR4: 2249159 -2263739
Locus: 4p16.3
Gene Diseases
The LETM1 MXD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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