LEPR-MEF2D Fusion FISH Probe
The LEPR-MEF2D Fusion FISH Probe is used to confirm a fusion of the LEPR and MEF2D genes. The fusion of the LEPR and MEF2D genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LEPR-MEF2D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-RERE | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-REOR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-REGO | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-REGR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-REAQ | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-ORRE | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-OROR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-ORGO | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-ORAQ | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GORE | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GOOR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GOGO | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GOGR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GOAQ | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GRRE | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GROR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GRGO | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GRGR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-GRAQ | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-AQRE | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-AQOR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-AQGO | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-AQGR | 20 (40 μL) | 200 μL |
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| LEPR-MEF2D-20-AQAQ | 20 (40 μL) | 200 μL |
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LEPR Gene Summary
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Gene Name: Leptin Receptor
Chromosome: CHR1: 65886334 -66103176
Locus: 1p31.3
MEF2D Gene Summary
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Name: Myocyte Enhancer Factor 2D
Chromosome: CHR1: 156433518 -156470529
Locus: 1q22
Gene Diseases
The LEPR MEF2D Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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