LEO1-FBN1 Fusion FISH Probe
The LEO1-FBN1 Fusion FISH Probe is used to confirm a fusion of the LEO1 and FBN1 genes. The fusion of the LEO1 and FBN1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LEO1-FBN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-RERE | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-REOR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-REGO | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-REGR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-REAQ | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-ORRE | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-OROR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-ORGO | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GORE | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GOOR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GOGO | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GOGR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GRRE | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GROR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GRGO | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GRGR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-AQRE | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-AQOR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-AQGO | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-AQGR | 20 (40 μL) | 200 μL |
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| LEO1-FBN1-20-AQAQ | 20 (40 μL) | 200 μL |
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FBN1 Gene Summary
This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016]
Gene Name: Fibrillin 1
Chromosome: CHR15: 48700502 -48937985
Locus: 15q21.1
LEO1 Gene Summary
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Gene Name: LEO1 Homolog, Paf1/RNA Polymerase II Complex Component
Chromosome: CHR15: 52230221 -52263958
Locus: 15q21.2
Gene Diseases
The LEO1 FBN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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