LEMD3-TSPAN8 Fusion FISH Probe
The LEMD3-TSPAN8 Fusion FISH Probe is used to confirm a fusion of the LEMD3 and TSPAN8 genes. The fusion of the LEMD3 and TSPAN8 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LEMD3-TSPAN8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-RERE | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-REOR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-REGO | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-REGR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-REAQ | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-ORRE | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-OROR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-ORGO | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-ORAQ | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GORE | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GOOR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GOGO | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GOGR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GOAQ | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GRRE | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GROR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GRGO | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GRGR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-GRAQ | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-AQRE | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-AQOR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-AQGO | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-AQGR | 20 (40 μL) | 200 μL |
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| LEMD3-TSPAN8-20-AQAQ | 20 (40 μL) | 200 μL |
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TSPAN8 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Tetraspanin 8
Chromosome: CHR12: 71518876 -71551779
Locus: 12q21.1
LEMD3 Gene Summary
This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
Gene Name: LEM Domain Containing 3
Chromosome: CHR12: 65563350 -65642141
Locus: 12q14.3
Gene Diseases
The LEMD3 TSPAN8 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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