LDLR-TNPO2 Fusion FISH Probe
The LDLR-TNPO2 Fusion FISH Probe is used to confirm a fusion of the LDLR and TNPO2 genes. The fusion of the LDLR and TNPO2 genes has been associated with Breast Invasive Carcinoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LDLR-TNPO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-RERE | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-REOR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-REGO | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-REGR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-REAQ | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-ORRE | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-OROR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-ORGO | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GORE | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GOOR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GOGO | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GOGR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GRRE | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GROR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GRGO | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GRGR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-AQRE | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-AQOR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-AQGO | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-AQGR | 20 (40 μL) | 200 μL |
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| LDLR-TNPO2-20-AQAQ | 20 (40 μL) | 200 μL |
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LDLR Gene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Gene Name: Low Density Lipoprotein Receptor
Chromosome: CHR19: 11200037 -11244505
Locus: 19p13.2
TNPO2 Gene Summary
The Transportin 2 (TNPO2) gene is located on chr19 :12810007-12834810 at 19p13.13.
Gene Name: Transportin 2
Chromosome: CHR19: 12810007 -12834810
Locus: 19p13.13
Gene Diseases
The LDLR TNPO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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