LBP-BPI Fusion FISH Probe
The LBP-BPI Fusion FISH Probe is used to confirm a fusion of the LBP and BPI genes. The fusion of the LBP and BPI genes has been associated with Kidney Renal Papillary Cell Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LBP-BPI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-RERE | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-REOR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-REGO | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-REGR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-REAQ | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-ORRE | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-OROR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-ORGO | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-ORAQ | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GORE | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GOOR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GOGO | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GOGR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GOAQ | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GRRE | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GROR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GRGO | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GRGR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-GRAQ | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-AQRE | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-AQOR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-AQGO | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-AQGR | 20 (40 μL) | 200 μL |
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| LBP-BPI-20-AQAQ | 20 (40 μL) | 200 μL |
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BPI Gene Summary
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Gene Name: Bactericidal/permeability-increasing Protein
Chromosome: CHR20: 36932551 -36965905
Locus: 20q11.23
LBP Gene Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Gene Name: Lipopolysaccharide Binding Protein
Chromosome: CHR20: 36974884 -37005653
Locus: 20q11.23
Gene Diseases
The LBP BPI Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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