LATS2-MYLK Fusion FISH Probe
The LATS2-MYLK Fusion FISH Probe is used to confirm a fusion of the LATS2 and MYLK genes. The fusion of the LATS2 and MYLK genes has been associated with Sarcoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LATS2-MYLK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-RERE | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-REOR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-REGO | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-REGR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-REAQ | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-ORRE | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-OROR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-ORGO | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-ORAQ | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GORE | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GOOR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GOGO | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GOGR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GOAQ | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GRRE | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GROR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GRGO | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GRGR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-GRAQ | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-AQRE | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-AQOR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-AQGO | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-AQGR | 20 (40 μL) | 200 μL |
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| LATS2-MYLK-20-AQAQ | 20 (40 μL) | 200 μL |
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MYLK Gene Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Light Chain Kinase
Chromosome: CHR3: 123331142 -123603149
Locus: 3q21.1
LATS2 Gene Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Gene Name: Large Tumor Suppressor Kinase 2
Chromosome: CHR13: 21547175 -21635722
Locus: 13q12.11
Gene Diseases
The LATS2 MYLK Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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