LATS1-LACE1 Fusion FISH Probe
The LATS1-LACE1 Fusion FISH Probe is used to confirm a fusion of the LATS1 and LACE1 genes. The fusion of the LATS1 and LACE1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LATS1-LACE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-RERE | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-REOR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-REGO | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-REGR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-REAQ | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-ORRE | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-OROR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-ORGO | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GORE | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GOOR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GOGO | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GOGR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GRRE | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GROR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GRGO | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GRGR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-AQRE | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-AQOR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-AQGO | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-AQGR | 20 (40 μL) | 200 μL |
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| LATS1-LACE1-20-AQAQ | 20 (40 μL) | 200 μL |
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LATS1 Gene Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Gene Name: Large Tumor Suppressor Kinase 1
Chromosome: CHR6: 149982050 -150039392
Locus: 6q25.1
Gene Diseases
The LATS1 LACE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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