LARS2-TBL1XR1 Fusion FISH Probe
The LARS2-TBL1XR1 Fusion FISH Probe is used to confirm a fusion of the LARS2 and TBL1XR1 genes. The fusion of the LARS2 and TBL1XR1 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LARS2-TBL1XR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-RERE | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-REOR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-REGO | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-REGR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-REAQ | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-ORRE | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-OROR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-ORGO | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GORE | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GOOR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GOGO | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GOGR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GRRE | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GROR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GRGO | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GRGR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-AQRE | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-AQOR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-AQGO | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-AQGR | 20 (40 μL) | 200 μL |
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| LARS2-TBL1XR1-20-AQAQ | 20 (40 μL) | 200 μL |
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LARS2 Gene Summary
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Gene Name: Leucyl-tRNA Synthetase 2, Mitochondrial
Chromosome: CHR3: 45430074 -45590328
Locus: 3p21.31
TBL1XR1 Gene Summary
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Gene Name: Transducin Beta Like 1 X-linked Receptor 1
Chromosome: CHR3: 176738541 -176915048
Locus: 3q26.32
Gene Diseases
The LARS2 TBL1XR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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