LARP4B-PFKFB3 Fusion FISH Probe
The LARP4B-PFKFB3 Fusion FISH Probe is used to confirm a fusion of the LARP4B and PFKFB3 genes. The fusion of the LARP4B and PFKFB3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LARP4B-PFKFB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-RERE | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-REOR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-REGO | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-REGR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-REAQ | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-ORRE | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-OROR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-ORGO | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GORE | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GOOR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GOGO | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GOGR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GRRE | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GROR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GRGO | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GRGR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-AQRE | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-AQOR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-AQGO | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-AQGR | 20 (40 μL) | 200 μL |
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| LARP4B-PFKFB3-20-AQAQ | 20 (40 μL) | 200 μL |
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PFKFB3 Gene Summary
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Chromosome: CHR10: 6186842 -6277507
Locus: 10p15.1
LARP4B Gene Summary
This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Gene Name: La Ribonucleoprotein Domain Family Member 4B
Chromosome: CHR10: 855483 -931702
Locus: 10p15.3
Gene Diseases
The LARP4B PFKFB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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