LAMB1-TYK2 Fusion FISH Probe
The LAMB1-TYK2 Fusion FISH Probe is used to confirm a fusion of the LAMB1 and TYK2 genes. The fusion of the LAMB1 and TYK2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMB1-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMB1-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMB1 Gene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
Gene Name: Laminin Subunit Beta 1
Chromosome: CHR7: 107564245 -107643804
Locus: 7q31.1
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The LAMB1 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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