LAMB1-NRCAM Fusion FISH Probe
The LAMB1-NRCAM Fusion FISH Probe is used to confirm a fusion of the LAMB1 and NRCAM genes. The fusion of the LAMB1 and NRCAM genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMB1-NRCAM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-RERE | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-REOR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-REGO | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-REGR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-OROR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GORE | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GROR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMB1-NRCAM-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMB1 Gene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
Gene Name: Laminin Subunit Beta 1
Chromosome: CHR7: 107564245 -107643804
Locus: 7q31.1
NRCAM Gene Summary
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Neuronal Cell Adhesion Molecule
Chromosome: CHR7: 107788070 -108096841
Locus: 7q31.1
Gene Diseases
The LAMB1 NRCAM Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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