LAMA5-WFDC2 Fusion FISH Probe
The LAMA5-WFDC2 Fusion FISH Probe is used to confirm a fusion of the LAMA5 and WFDC2 genes. The fusion of the LAMA5 and WFDC2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA5-WFDC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA5-WFDC2-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA5 Gene Summary
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Gene Name: Laminin Subunit Alpha 5
Chromosome: CHR20: 60884120 -60942368
Locus: 20q13.33
WFDC2 Gene Summary
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Gene Name: WAP Four-disulfide Core Domain 2
Chromosome: CHR20: 44098393 -44110172
Locus: 20q13.12
Gene Diseases
The LAMA5 WFDC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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