LAMA5-SEC63 Fusion FISH Probe
The LAMA5-SEC63 Fusion FISH Probe is used to confirm a fusion of the LAMA5 and SEC63 genes. The fusion of the LAMA5 and SEC63 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA5-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA5-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA5 Gene Summary
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Gene Name: Laminin Subunit Alpha 5
Chromosome: CHR20: 60884120 -60942368
Locus: 20q13.33
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The LAMA5 SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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