LAMA5-NCOR2 Fusion FISH Probe
The LAMA5-NCOR2 Fusion FISH Probe is used to confirm a fusion of the LAMA5 and NCOR2 genes. The fusion of the LAMA5 and NCOR2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA5-NCOR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA5-NCOR2-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA5 Gene Summary
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Gene Name: Laminin Subunit Alpha 5
Chromosome: CHR20: 60884120 -60942368
Locus: 20q13.33
NCOR2 Gene Summary
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Name: Nuclear Receptor Corepressor 2
Chromosome: CHR12: 124808956 -125052010
Locus: 12q24.31
Gene Diseases
The LAMA5 NCOR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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