LAMA5-CLCN7 Fusion FISH Probe
The LAMA5-CLCN7 Fusion FISH Probe is used to confirm a fusion of the LAMA5 and CLCN7 genes. The fusion of the LAMA5 and CLCN7 genes has been associated with Rectum Adenocarcinoma, and Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA5-CLCN7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA5-CLCN7-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN7 Gene Summary
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]
Gene Name: Chloride Voltage-gated Channel 7
Chromosome: CHR16: 1494934 -1525085
Locus: 16p13.3
LAMA5 Gene Summary
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
Gene Name: Laminin Subunit Alpha 5
Chromosome: CHR20: 60884120 -60942368
Locus: 20q13.33
Gene Diseases
The LAMA5 CLCN7 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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