LAMA3-CABLES1 Fusion FISH Probe
The LAMA3-CABLES1 Fusion FISH Probe is used to confirm a fusion of the LAMA3 and CABLES1 genes. The fusion of the LAMA3 and CABLES1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA3-CABLES1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA3-CABLES1-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA3 Gene Summary
The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Laminin Subunit Alpha 3
Chromosome: CHR18: 21269561 -21535029
Locus: 18q11.2
CABLES1 Gene Summary
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Cdk5 And Abl Enzyme Substrate 1
Chromosome: CHR18: 20714527 -20840434
Locus: 18q11.2
Gene Diseases
The LAMA3 CABLES1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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