LAMA2-UQCRB Fusion FISH Probe
The LAMA2-UQCRB Fusion FISH Probe is used to confirm a fusion of the LAMA2 and UQCRB genes. The fusion of the LAMA2 and UQCRB genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA2-UQCRB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA2-UQCRB-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA2 Gene Summary
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Laminin Subunit Alpha 2
Chromosome: CHR6: 129204285 -129837710
Locus: 6q22.33
UQCRB Gene Summary
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
Gene Name: Ubiquinol-cytochrome C Reductase Binding Protein
Chromosome: CHR8: 97239303 -97247862
Locus: 8q22.1
Gene Diseases
The LAMA2 UQCRB Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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