LAMA2-GRIK2 Fusion FISH Probe
The LAMA2-GRIK2 Fusion FISH Probe is used to confirm a fusion of the LAMA2 and GRIK2 genes. The fusion of the LAMA2 and GRIK2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAMA2-GRIK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-RERE | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-REOR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-REGO | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-REGR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-REAQ | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-ORRE | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-OROR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-ORGO | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GORE | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GOOR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GOGO | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GOGR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GRRE | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GROR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GRGO | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GRGR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-AQRE | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-AQOR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-AQGO | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-AQGR | 20 (40 μL) | 200 μL |
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| LAMA2-GRIK2-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIK2 Gene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Ionotropic Receptor Kainate Type Subunit 2
Chromosome: CHR6: 101846860 -102517958
Locus: 6q16.3
LAMA2 Gene Summary
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Laminin Subunit Alpha 2
Chromosome: CHR6: 129204285 -129837710
Locus: 6q22.33
Gene Diseases
The LAMA2 GRIK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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